EULAR 2018 | Daily Highlights

Antibodies in FMS

EVALUATION OF TISSUE SPECIFIC AUTOANTIBODIES IN FIBROMYALGIA PATIENTS WITH SICCA AND/OR XEROSTOMIA

Abstract: THU0508
Authors: E. Applbaum, A. Lichtbroun

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Key content:
This study aimed to examine the relationship between SS and fibromyalgia by testing patients with fibromyalgia, that also complain of xerostomia and sicca symptoms for Sjögren’s related autoantibodies SSA/Ro, SSB/La and the recently described Sjögren related tissue specific antibodies (TSA) against salivary gland protein 1 (SP-1), carbonic anhydrase 6 (CA6) and parotid secretory protein (PSP).

Patients that presented with symptoms of fibromyalgia and fulfilled both the 1990 and 2010 preliminary diagnostic criteria and complained of sicca symptoms were evaluated. Only patients who had the following criterias: Using artificial tears at least biweekly, drinking water excessively to relieve dry mouth, or have previously experienced a blocked tear duct, but did not meet the diagnostic criteria for SS and did not have elevated inflammatory markers ESR or CRP, were selected for this study. In this study population Sjögren’s related biomarkers SSA/Ro, SSB/La, SP-1, CA6, and PSP were measured.

From the 310 patients fulfilling the above criteria about 1/3 were tested positive for one or more of the TSAs (SP-1, CA6, PSP) and classic Sjögren’s markers (SSA/Ro, SSB/La), with the majority of those patients being positive for one or more of the TSAs.

Relevance:
This study implicates that patients with fibromyalgia and sicca symptoms should be thoroughly examined for underlying Sjögren’s disease.

Zusammenfassung und Kommentar von:
Dr. Thomas Langenegger
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